Main difference: turn (Sombra -1 vs Rune 0). The Sombra turns over more easily (better for less power or turnover shots); the Rune resists turn and holds a hyzer.
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FAQ
Is the Sombra or Rune more overstable?
The Rune is more overstable (stability +0 vs -1). It resists turning and fades harder.
Should a beginner pick the Sombra or Rune?
A beginner is better off with the Sombra (beginner score 68/100 vs 63/100) - lower speed and more turn make it easier to control.
What is the difference between the Sombra and Rune?
Main difference: turn (Sombra -1 vs Rune 0). The Sombra turns over more easily (better for less power or turnover shots); the Rune resists turn and holds a hyzer.